Bell Canada set to launch Novatel's MiFi 2

Novatel's touchable MiFi 2 -- also known as the MiFi Liberate -- receives a fresh coat of paint in the form of a UI overhaul on its way to Bell Canada's network this March. No word on pricing or an exact date, but this 11-hour-lasting king of all portable access points is $50 on a two-year agreement on AT&T, so we'd hazard that sets a decent watermark on the potential price. No word on what the new UI tweaks entail but we're angling to get our hands on one some time this week at Mobile World Congress in Barcelona.

Filed under: Peripherals, Wireless

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Source: http://www.engadget.com/2013/02/24/bell-canada-set-to-launch-novatels-mifi-2/

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Distinct niches in bone marrow nurture blood stem cells

Monday, February 25, 2013

In research that could one day improve the success of stem cell transplants and chemotherapy, scientists have found that distinct niches exist in bone marrow to nurture different types of blood stem cells.

Stem cells in the blood are the precursors to infection-fighting white blood cells and oxygen-carrying red blood cells.

The research, by a team at Washington University School of Medicine in St. Louis, is reported Feb. 24 in the advance online edition of Nature.

The new findings, in mice, suggest that it may be possible to therapeutically target support cells in a particular niche. On the one hand, a drug that nourishes support cells could encourage blood stem cells to establish themselves in the bone marrow, enabling patients who have had stem cell transplants to more quickly rebuild their immune systems.

On the other, tumor cells are known to hide in the bone marrow, and a drug that disrupts the niche environment may drive cancer cells into the bloodstream, where they are more vulnerable to the damaging effects of chemotherapy.

"Our results offer hope for targeting these niches to treat specific cancers or to improve the success of stem cell transplants," says senior author Daniel Link, MD, the Alan A. and Edith L. Wolff Professor of Medicine. "Already, we and others are leading clinical trials to evaluate whether it is possible to disrupt these niches in patients with leukemia or multiple myeloma."

Working in the mice, the researchers selectively deleted a critical gene, CXCL12, which is known to be important for keeping blood stem cells healthy. Rather than knock out the gene in all of the support cells in a niche, the researchers deleted the gene in specific types of support cells. This led to the discovery that each niche holds only certain blood stem cells that are nourished by a unique set of support cells.

"What we found was rather surprising," Link says. "There's not just one niche for developing blood cells in the bone marrow. There's a distinct niche for stem cells, which have the ability to become any blood cell in the body, and a separate niche for infection-fighting blood cells that are destined to become T cells and B cells."

The findings provide a strong foundation for investigating whether disrupting these niches can improve the effectiveness of chemotherapy.

In a phase II pilot study led by Washington University medical oncologist Geoffrey Uy, MD, assistant professor of medicine, Link is evaluating whether the drug G-CSF can alter the stem cell niche in patients with acute lymphoblastic leukemia whose cancer has recurred or is resistant to treatment. The drug was approved by the Food and Drug Administration more than 20 years ago to stimulate production of white blood cells in patients undergoing chemotherapy, who often have weakened immune systems and are prone to infections.

But Uy and colleagues will evaluate the drug when it is given before chemotherapy. Patients enrolled in the trial at the Siteman Cancer Center will receive G-CSF for five days before chemotherapy, and the investigators will determine whether it can disrupt the protective environment of the bone marrow niche and make cancer cells more sensitive to chemotherapy.

While it's too early to know whether the treatment approach will be successful, Link's new research in mice is bolstered by a companion paper in the same issue of Nature. In that research, Sean Morrison, PhD, director of the Children's Medical Center Research Institute at the University of Texas Southwestern Medical Center in Dallas, used similar molecular methods to also discover distinct niches in the bone marrow for blood stem cells.

"There's a lot of interest right now in trying to understand these niches," Link adds. "Both of these studies add new information that will be important as we move forward. Next, we hope to understand how stem cell niches can be manipulated to help patients undergoing stem cell transplants."

###

Greenbaum A, Hsu Y-MS, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC. CXCL12 production by early mesenchymal progenitors is required for haemoatopoietic stem-cell maintenance. Nature. Advance online publication Feb. 24, 2013.

Washington University School of Medicine: http://www.medicine.wustl.edu

Thanks to Washington University School of Medicine for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126999/Distinct_niches_in_bone_marrow_nurture_blood_stem_cells

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Boston Marathon Runner Climbs Hills In Fight To Cure Cancer

MILFORD, Mass. ? Jamie Gornstein Tighe wakes up at 4:30 a.m. on weekdays and immediately hops on a treadmill. On Saturdays, she gets to sleep in until 6 a.m. before heading out in to the cold and running 10 to 20 miles. But it could be worse.

?Long runs are hard, but it?s not chemo,? said Tighe, a Franklin resident. ?When I?m done, I?ll be sore and I won?t be able to walk for a day or two. But people going through cancer won?t have that luxury. They?re going through an extremely painful experience.

?I just tell myself to suck it up ? you?re not going through cancer."

Tighe doesn?t consider herself a true runner. But in April, she?ll be running her second Boston Marathon with the Dana-Farber Marathon Challenge team. Every dollar she raises supports the Claudia Adams Barr Program in Innovative Basic Cancer Research, which funds the ?brightest, most creative scientists making basic research discoveries.?

In 2011, Tighe raised more than $12,000 in memory of her close friend Andy Swan, who died at age 35 from Stage IV lung cancer.

?Andy was a non-smoker and in excellent health,? she said. ?This diagnosis came completely out of left field. And he died 10 months after diagnosis, leaving behind his wife and 4-year-old son. He was a filmmaker with a bright future, and it was such a devastating blow.

?His father is now battling prostate cancer and is also being treated by Dana-Farber. This year I am running in Andy?s memory and in honor of Bob, Andy?s father. My goal is just shy of $13,000, as I want to raise $25,000 for my two marathons.?

Tighe said she has already raised more than $6,500 on Facebook, and she is organizing a fundraiser for April 6 with current and former players from the Patriots and Celtics. The fundraiser is tentatively planned for 3 to 6 p.m. at CJ?s in Framingham.

?I have every confidence that people will help me get to that goal,? she said. ?I?m hoping every little bit adds up, and I can reach that goal of $12,880.?

Tighe, who has daughters in second and sixth grades, is a special needs job coach at Medway High School. As a result, her only time to train is before the sun comes up.

?You do what you got to do,? she said. ?That?s part of being a mom and working. But it?s such an important cause, and the time has to go in. It?s also great for my girls to see this, so they?re inspired to do something like this.?

On Saturdays, Tighe joins her Dana-Farber teammates for long group runs. Most of the runs are on the Boston Marathon course with hilly routes to prepare them for Heartbreak Hill and for the 26.2-mile race, she said.

But it?s not just the team's camaraderie that helps her through the marathon training.

?I couldn't do this without my husband Kevin?s support,? Tighe said. ?He takes our daughters to their basketball games every Saturday so I can run, and then he takes care of them when I am trying to recover.

?And he's a great masseuse, post-run,? she added.

For more information about Tighe?s fundraising, visit her page.

The Daily Voice is profiling local runners who are running the Boston Marathon for charity. Email jpaluzzi@dailyvoice.com?to have your story told.

Source: http://northborough.dailyvoice.com/sports/boston-marathon-runner-climbs-hills-fight-cure-cancer

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Satellite television on pc or satellite television is television delivered through orbiting communications satellites located 37,000 km above the earth's surface.

cardsharing - The initial satellite tv signal was relayed from Europe for your Telstar satellite over The united states in 1962. The first domestic United states of america satellite to carry television was Canada's Anik 1, that has been launched in 1973.

Satellite TV, like other communications relayed by satellite, starts off with a transmitting satellite antenna in an uplink facility. Uplink satellite dishes are targeted at the satellite what needs signals will be transmitted to, and so are large, as much as 9 to 12 meters (30 to 40 feet) in diameter. The greater the dish, the more often accurate positioning and improved signal reception about the satellite. The television signals is transmitted to devices located on-board the satellite called transponders, which retransmit the satellite signal back towards the Earth using a different frequency.

The satellite signal, quite weak after traveling through space, is collected having a parabolic receiving dish, which reflects the weak signal for the dish's centerpiece and it is received, down-converted for some lower frequency band and amplified by using a device known as a low-noise block down converter, or LNB.

A brand new type of satellite antenna, that won't use a directed parabolic dish and could be utilized on a mobile platform for instance a vehicle, was recently announced by the University of Waterloo. On popularly known as car satellite system.

The satellite television signal, now amplified, travels with a satellite television on pc receiver box through coaxial cable (RG-6 or RG-10; can't be standard RG-59) and is also converted by using a local oscillator to the L-band variety of frequencies (approximately). Special on-board electronics within the receiver box help tune the signal then convert it having a frequency a standard television may use.

While you known, tv business in United states mostly are dominated by two companies, Dish Network and DirecTV. In order to get yourself a satellite television on pc in your own home, your options mostly are restricted to the disposable tv packages that made available from every one Dish Network or DirecTV.

This is a quick take on Usa tv industry: Hughes's DirecTV, the original high-powered DBS system, went online in 1994 called the first Us DBS service. In 1996, Echostar's Dish Network went online in the usa and contains gone to similar success.

Source: http://www.proman-help.isys-informatik.ch/index.php/Benutzer%3AKinderLandon265

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Former GOP presidential candidate Huntsman backs gay marriage

Former Utah Governor Jon Huntsman speaks at the Myrtle Beach Convention Center in Myrtle Beach, South Carolina January 16, 2012. REUTERS/Chr

(Reuters) - Former Republican presidential candidate Jon Huntsman voiced support for gay marriage on Thursday, reversing his position and urging the Republican Party to be more supportive of gays and lesbians who want to marry.

Huntsman, a former U.S. ambassador to China and governor of Utah widely viewed as a moderate, made the announcement in an op-ed piece published online in The American Conservative magazine.

"I've been married for 29 years. My marriage has been the greatest joy of my life," he wrote. "There is nothing conservative about denying other Americans the ability to forge that same relationship with the person they love."

His comments appeared in an article titled "Marriage Equality Is a Conservative Cause."

"Today we have an opportunity to do more: conservatives should start to lead again and push their states to join the nine others that allow all their citizens to marry," Huntsman wrote.

Nine of the 50 U.S. states plus the District of Columbia have legalized gay marriage. Maryland was the most recent, with gay marriage becoming legal there on January 1.

Huntsman backed civil unions for gays and lesbians when he was governor of Utah. While he ran for the Republican presidential nomination, Huntsman told CNN, "I don't think you can redefine marriage from the traditional sense."

Huntsman abandoned his bid for the Republican nomination in January 2012 after his campaign failed to gain traction and he finished third in the New Hampshire primary.

(Reporting by Kevin Gray; Editing by Paul Thomasch and Andrew Hay)

Source: http://wkzo.com/news/articles/2013/feb/21/former-gop-presidential-candidate-huntsman-backs-gay-marriage/

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TechCrunch Mobile Barcelona Meetup 2013 ? Here Are Our Shortlisted Startups

Barcelona is coming alive with preparations for Mobile World Congress and we are pumped about the super-international TechCrunch Mobile Barcelona meetup in the same week. With thanks to our local supporters in the shape of Barcelona.io and Wayra, we'll be bringing you a healthy round of startups, VCs and TechCrunch writers to while away your evening. The hashtag for the event will be #TCMB. Here's our line-up.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/FFB7NrGckIE/

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What Are the Best Apps to Help Me Prepare My Taxes?

Dear Lifehacker,
I'm getting ready to do my taxes soon and would like to know if there are any good mobile apps or websites that will make this less painful and stressful (besides the obvious tax prep tools, of course). Help me get all the stuff I need organized!

Signed,
Taxed by Taxes

Dear Taxed,
Ah, tax season. Just the thought of it gives some of us headaches. The good news is there are lots of free and inexpensive apps and tools that can greatly simplify this awful process, from getting organized to filing your return. Here's what we recommend.

Get Your Tax Documents in Order

If you have an uncomplicated return (one W2, for example, and take the standard deduction), congratulations: You don't have to worry much about organizing your tax records. For everyone else, though, managing the piles of receipts and other documents is a big part of the pain. Several apps can help with that.

Evernote: The Swiss Army knife of note taking and capture tools, Evernote excels at keeping your documents categorized into notebooks. You can set up a tax notebook and then either sub-notebooks or tags for different categories like income statements, interest earned, charitable contributions, and the like. Combine Evernote with compact scanner Doxie or ScanSnap, and you can quickly file your receipts in Evernote. Another strategy is to use webapp automation service IFTTT to automatically send any emails you tag in Gmail with a tax label to your Evernote tax notebook. Handy!

Shoeboxed: If scanning and managing all those papers isn't your thing, take a look at receipt scanning solution Shoeboxed. As we've previously mentioned, you can mail, email, or upload your receipts to Shoeboxed and they'll OCR and categorize the documents for you. You can export those receipts to popular tax programs, as well as Evernote, and mobile apps are available. A free account lets you store 5 documents per month, while premium plans starting at $9.95 give you more capacity.

Slice: Slice is a brilliant receipt and package tracking webapp and mobile app. It scans your Gmail for receipts and gives you an overview of your entire purchase history. Last year, I used the convenient listing to find tax-deductible receipts I had forgotten about.

Expensify: If you can take deductible expenses like car mileage and meals and entertainment expenses when you travel for business, Expensify has your back. The mobile apps and web receipts extension capture all those stray receipts and attachments and can turn them into IRS-approved eReceipts. It's a great app for independent contractors.

Your personal finance program and financial accounts: Of course, don't forget to consult your personal finance tool, such as popular Mint or Quicken to see spending by category and find all those deductible expenses. Both can port your information to TurboTax.

Also, your year-end statements from your credit card or bank can also come in handy if you're hunting down your tax-related expenses. (American Express has an awesome searchable and sortable view of statements by category.)

Get Free Tax Information

TaxCaster by TurboTax: Want a sneak peek at how much of a refund (or tax bill) you'll get this year? This free tax refund calculator will estimate your taxes based on your quick inputs. It's available online, for Android, and for iOS.

Bloomberg BNA Quick Tax Reference: This app for Android, iPhone, and BlackBerry gives you instant access to tax rates and other handy information, such as IRA limits, mileage rates, and more. It's developed for financial professionals, but also offers useful tools like quickly calculating your total tax.

TaxACT Central: A companion app to the popular, free tax filing service, TaxACT Central can answer your tax questions and keep you organized, with a convenient checklist of what you need to file. You don't have to use TaxACT for filing to make use of the Android or iPhone app.

File Your Taxes and Monitor Your Refund

We generally recommend going to a tax professional unless you have a very simple return. If yours isn't complicated, though, mobile and desktop apps can streamline filing your return and tracking your refund.

TurboTax SnapTax: You can file your taxes in as little as ten minutes using this simple Android and iPhone app. Snap a photo of your W2, answer a few questions, and file right from the phone or online. (Isn't the future great?) This app is only for those who: make under $100,000 ($120,000 if married); only have W2, interest, or unemployment income; and don't own a home. Free to try, but $24.99 to file both federal and state.

H&R Block also offers mobile tax apps. The 1040EZ for Smartphone prepares your simple federal and state returns for free on Android and iPhone. There's also a iPad app not limited to 1040EZ returns, with free federal filing for simple returns and an additional fee for state filing.

Of course, both of these tax services (and many others) have desktop and/or webapps. Not all tax preparation software will give you the same results, though. ConsumerSearch has rounded up reviews of the top four tax prep applications, and Get Rich Slowly has an excellent (yet older) price comparison of these solutions and services.

IRS2Go: From Uncle Sam himself, IRS2Go doesn't let you file taxes from the Android or iPhone apps, but you can check the status of your refund, get tax law updates, request a copy of your tax records in the mail, and watch IRS YouTube videos. (Perhaps not the most exciting download, but we are talking about the IRS and taxes here.)

Grab these apps and put them in a new tax organization folder and you'll be set for this tax season and beyond.

Love,
Lifehacker

Have a question or suggestion for Ask Lifehacker? Send it to tips+asklh@lifehacker.com.

Photo remixed from an original by Nejron Photo (Shutterstock)

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/eEsew6KLUy8/what-are-the-best-apps-to-help-me-prepare-my-taxes

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