Andy Samberg Is Engaged To Joanna Newsom “Like A Boss!” (Photos)
Andy Samberg Is Engaged To Joanna Newsom “Like A Boss!” (Photos) Stupid Celebrities Gossip Stupid Celebrities Gossip News
Source: http://stupidcelebrities.net/2013/02/andy-samberg-is-engaged-to-joanna-newsom-like-a-boss-photos/
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In 1924, The National Barn Dance made its debut over WLS Radio/Chicago. The show was the first to blend folk and country music with rural humor. The legendary Gene Autry, Pat Buttram, George Gobel, Andy Williams and Eddie Peabody were all regular members of the shows cast The National Barn Dance rapidly grew in popularity and was the idea behind Nashvilles Grand Ole Opry.
Duke Miglin, current building owner and noted Chicago developer, is making the space available for the celebration. The historic studio will soon be transformed into office space.
Celebration attendees will receive a limited edition poster commemorating the 89th anniversary of The National Barn Dance. The program was inducted into the National Radio Hall of Fame in 2011.
WLS Radio is a promotional sponsor of the celebration. Rubschlager Baking Corporation is an event sponsor and will provide light refreshments.
Stephen Parry is the writer/producer of the PBS documentary The Hayloft Gang that chronicles the history of the WLS National Barn Dance. Highlights of the documentary will be presented.
Seminar speakers include:
Attendees will receive a limited edition poster commemorating the 89th Anniversary the WLS National Barn Dance.
Saturday, March 23, 2013, at 3 p.m. Tickets are $89 each and can be purchased here or by phone at 312-624-8010. (Limited Seating). 1230 W Washington Blvd, Chicago, IL 60607. The site of the historic WLS radio studio where the National Barn Dance once originated.
Source: http://www.cybergrass.com/node/2294
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Scientists' findings disclose a new and much needed test for river blindness infection
Tuesday, February 26, 2013Scientists at The Scripps Research Institute (TSRI) have found a telltale molecular marker for Onchocerciasis or "river blindness," a parasitic infection that affects tens of millions of people in Africa, Latin America and other tropical regions. The newly discovered biomarker, detectable in patients' urine, is secreted by Onchocerca volvulus worms during an active infection. The biomarker could form the basis of a portable, field-ready test with significant advantages over current diagnostic methods.
"There has been a need for an inexpensive, non-invasive test that can discriminate between active and non-active river blindness infections during treatment campaigns," said Kim D. Janda, who is Professor and Ely R. Callaway, Jr. Chair in Chemistry, member of the Skaggs Institute for Chemical Biology, and director of the Worm Institute of Research and Medicine at TSRI. "We think that this new biomarker can be the basis for such a test."
The work is described in an online Early Edition of the Proceedings of the National Academy of Sciences during the week of February 25, 2013.
Leading Cause of Vision Loss
A leading cause of vision loss, Onchocerciasis infections are transmitted among humans by river-dwelling blackflies in tropical regions. The vast majority of cases occur in sub-Saharan Africa, although pockets of endemic infection exist in Yemen and in Central and South America. The major symptoms of the disease, including blindness, result from the spread of O. volvulus "microfilariae"?early-stage larval worms?to the eyes and other tissues, where they trigger damaging inflammatory reactions.
Mass treatment campaigns, begun in the 1990s, have used the anti-worm drug ivermectin, as well as the antibiotic doxycycline, which kills a symbiotic bacterium within the worms. The World Health Organization's African Programme for Onchocerciasis Control has set a target date of 2025 for the eradication of the disease in that region. But Onchocerciasis treatment is seldom effective immediately and often spares adult worms. The latter can remain in protected nodules under the skin of a patient and secrete microfilaria for a decade or more. Health agencies need better diagnostic methods not only to monitor the progress of Onchocerciasis treatment campaigns, but also to limit the use of ivermectin and doxycycline to reduce the risk of resistance.
Current diagnostic methods include the painful cutting of "skin snips" from patients for microscopic analysis and an ELISA antibody test for microfilariae, which may yield positive results even for non-active infections. "You can still have circulating antibodies to a nemotode antigen in your blood for a long time after the infection is gone," said Janda.
Looking for a Better Way
A better diagnostic marker would be a metabolite of O. volvulus that appears only during an active, microfilariae-producing infection and that could determine both the presence and the severity of disease. In 2010, Janda's laboratory demonstrated the feasibility of this approach by sifting through the small-molecule metabolites within blood samples from river blindness patients?a technique called "metabolome mining"?and finding a set linked to active onchocerciasis infection. For the new study, the team sought a simpler set of biomarkers?or better yet, a single unique biomarker in urine.
Daniel Globisch, a postdoctoral fellow in the Janda laboratory, started with samples of urine from onchocerciasis-infected and non-infected Africans. Using a powerful laboratory technique called liquid chromatography mass spectrometry, he measured the concentrations of hundreds of small-molecule metabolites in the samples. Excitingly, between the infected and non-infected urine samples, one difference stood out clearly: "An unknown small molecule was highly elevated in the samples from infected individuals," said Globisch.
In a process akin to looking for the proverbial needle in the haystack, Globisch was able to purify the mysterious metabolite, and, using mass spectrometry, determine the chemical identities of its individual pieces. "The metabolite itself wasn't present in the databases, so I searched the literature for what is known about the biosynthesis and metabolic pathways in these nematodes," Globisch said. Ultimately, he was able to identify the metabolite as N-acetyltyramine-O,?-glucuronide. Remarkably, this molecule's inception can be traced to O. volvulus as a neurotransmitter molecule that is secreted by young, reproducing worms and then modified by the human body on its way to being excreted in urine.
"It's a spectacular find in terms of biomarkers as it does not occur naturally in humans," Globisch said. Levels of the metabolite in a non-infected North American control sample were near zero.
Toward a Field Test
In urine samples from Africans with active onchocerciasis infections, Globisch found that levels of the biomarker were on average four to six times higher than in samples from Africans with non-active infections. In a separate test, the team determined that a full course of doxycycline treatment, which sterilizes or kills infecting worms by destroying their symbiotic bacteria, also reduced levels of the biomarker to near-normal. "This biomarker appears to be specific for an active infection," Globisch said. The wide gap between biomarker levels in active and non-active infections suggests that a field test based on the biomarker would be robustly useful.
Such a diagnostic, said Janda, might ultimately be a simple urine dipstick test, much like a home pregnancy test, which would indicate the amount of the O. volvulus biomarker present in the sample. "Ultimately for this to be of value in Third World countries we will need to morph this biomarker into something that's inexpensive, simple to use, tolerant of extreme temperatures and portable?basically distilling our finding to a test that can be carted around in a backpack," Janda said.
Importantly, he adds that Globisch's metabolome-mining approach in theory should be applicable to the development of diagnostic tests for other worm diseases.
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Scripps Research Institute: http://www.scripps.edu
Thanks to Scripps Research Institute for this article.
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MTV News' memorable run-ins with Kristen Stewart, Jennifer Lawrence and other A-listers — with co-host Al Roker?
By Josh Horowitz
Kristen Stewart at the 2013 Oscars
Photo: Getty Images
Source: http://www.mtv.com/news/articles/1702524/oscars-2013-red-carpet-best-moments.jhtml
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ALMATY (Reuters) - Major powers will offer Iran some sanctions relief during talks in Almaty, Kazakhstan, this week if Tehran agrees to curb its nuclear program, a U.S. official said on Monday.
But the Islamic Republic could face more economic pain if it fails to address international concerns about its atomic activities, the official said ahead of the February 26-27 meeting in the central Asian state, speaking on condition of anonymity.
"There will be continued sanctions enforcement ... there are other areas where pressure can be put," the official said, on the eve of the first round of negotiations between Iran and six world powers in eight months.
A spokesman for European Union foreign policy chief Catherine Ashton, who leads the talks with Iran on behalf of the powers, said Tehran should understand that there was an "urgent need to make concrete and tangible progress" in Kazakhstan.
Both Russia and the United States stressed there was not an unlimited amount of time to resolve a dispute that has raised fears of a new war in the Middle East.
"The window for a diplomatic solution simply cannot by definition remain open forever. But it is open today. It is open now," U.S. Secretary of State John Kerry said in London.
"There is still time but there is only time if Iran makes the decision to come to the table and negotiate in good faith," he added in a news conference in London. "We are prepared to negotiate in good faith, in mutual respect, in an effort to avoid whatever terrible consequences could follow failure."
It was not clear what he meant by "terrible consequences." Top U.S. officials have repeatedly said the United States will not take any options off the table, code for the possibility of a military strike. They also fear Iran's getting a nuclear weapon could set off an arms race across the Middle East.
Russian Deputy Foreign Minister Sergei Ryabkov said there was "no more time to waste", Interfax news agency quoted him as saying in Almaty.
The immediate priority for the powers - the United States, Russia, China, Germany, Britain and France - is to convince Iran to halt its higher-grade enrichment, which is a relatively short technical step away from potential atom bomb material.
Iran, which has taken steps over the last year to expand its uranium enrichment activities in defiance of international demands to scale it back, wants a relaxation of increasingly harsh sanctions hurting its lifeline oil exports.
Western officials say the Almaty meeting is unlikely to produce any major breakthrough, in part because Iran's presidential election in June may make it difficult for it to make significant concessions before then for domestic reasons.
But they say they hope that Iran will take their proposals seriously and engage in negotiations to try to find a diplomatic settlement.
"No one is expecting to walk out of here with a deal but ... confidence building measures are important," one senior Western official said.
The stakes are high: Israel, assumed to be the Middle East's only nuclear-armed arsenal, has strongly hinted at possible military action to prevent its old foe from obtaining such arms. Iran has threatened to retaliate if attacked.
GOLD SANCTIONS RELIEF?
The U.S. official said the powers' updated offer to Iran - a modified version of one rejected by Iran in the unsuccessful talks last year - would take into account its recent nuclear advances, but also take "some steps in the sanctions arena".
This would be aimed at addressing some of Iran's concerns, the official said, while making clear it would not meet Tehran's demand of an easing of all punitive steps against it.
"We think ... there will be some additional sanctions relief" in the powers' revised proposal," the official said, without giving details.
Western diplomats have told Reuters the six countries will offer to ease sanctions on trade in gold and precious metals if Iran closes its Fordow underground uranium enrichment plant.
Iran has indicated, however, that this will not be enough.
Tehran denies Western allegations it is seeking to develop the capability to make nuclear bombs, saying its program is entirely peaceful. It wants the powers to recognize what it sees as its right to refine uranium for peaceful purposes.
The U.S. official said the powers hoped that the Almaty meeting would lead to follow-up talks soon.
"We are ready to step up the pace of our meetings and our discussions," the official said, adding the United States would also be prepared to hold bilateral talks with Tehran if it was serious about it.
Ashton's spokesman, Michael Mann, said the updated offer to Iran was "balanced and a fair basis" for constructive talks.
(Additional reporting by Yeganeh Torbati and Dimitry Solovyov and by Arshad Mohammed and Mohammed Abbas in London; Editing by Jon Hemming)
Source: http://news.yahoo.com/major-powers-offer-iran-sanctions-relief-nuclear-talks-125535303.html
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Advertising for Ikea meat balls at the parking area at an Ikea store in Malmo Sweden Monday Feb. 25, 2012. Furniture retailer Ikea says it has halted all sales of meat balls in Sweden after Czech authorities detected horse meat in frozen meatballs that were labeled as beef and pork. (AP Photo/Johannes Cleris) SWEDEN OUT
Advertising for Ikea meat balls at the parking area at an Ikea store in Malmo Sweden Monday Feb. 25, 2012. Furniture retailer Ikea says it has halted all sales of meat balls in Sweden after Czech authorities detected horse meat in frozen meatballs that were labeled as beef and pork. (AP Photo/Johannes Cleris) SWEDEN OUT
FILE - In this April 27, 2006 file photo, an exterior view of the Ikea furniture store in Duisburg, western Germany. The Czech veterinary authority said Monday, Feb. 25, 2013 it detected horse meat in meat balls labeled as beef and pork imported to the country by Sweden's furniture retailer giant Ikea. The State Veterinary Administration says the one-kilogram packs of the frozen meat balls were made in Sweden to be sold in Ikea's furniture stores that also offer typical Swedish food. (AP Photo/Frank Augstein, File)
FILE - In this Nov. 16, 2012 file photo, a sign bearing the Ikea logo is seen outside a store in Berlin. The Czech veterinary authority said Monday, Feb. 25, 2013 it detected horse meat in meat balls labeled as beef and pork imported to the country by Sweden's furniture retailer giant Ikea. The State Veterinary Administration says the one-kilogram packs of the frozen meat balls were made in Sweden to be sold in Ikea's furniture stores that also offer typical Swedish food. (AP Photo/Markus Schreiber, File)
Advertising for Ikea meat balls at the parking area at an Ikea store in Malmo Sweden Monday Feb. 25, 2012. Furniture retailer Ikea says it has halted all sales of meat balls in Sweden after Czech authorities detected horse meat in frozen meatballs that were labeled as beef and pork. (AP Photo/Johannes Cleris) SWEDEN OUT
STOCKHOLM (AP) ? Swedish furniture giant Ikea became entangled in Europe's widening meat scandal Monday, forced to withdraw meatballs from stores across Europe amid suspicions that they contained horse meat.
Stores in the U.S. and Canada were not affected, Ikea said.
The company reacted after authorities in the Czech Republic said they had detected horse DNA in tests of 1-kilogram (2.2-pound) packs of frozen meatballs that were labeled as beef and pork. The Czech State Veterinary Administration said it tested two batches of Ikea meatballs and only one of them contained horse meat. It did not say how much.
Meatballs from the same batch had been sent from a Swedish supplier to 12 other European countries ? Slovakia, Hungary, France, Britain, Portugal, the Netherlands, Belgium, Spain, Italy, Greece, Cyprus and Ireland ? and would be pulled off the shelves in all of them, Ikea said.
Later Monday, the company expanded the withdrawals to stores in 21 European countries and in Hong Kong, Thailand and the Dominican Republic, all of which were getting meatballs from the same Swedish supplier.
Ikea spokeswoman Ylva Magnusson said that included most European countries, but not Russia and Norway, which use local suppliers. Stores in Poland and Switzerland use both local suppliers and the Swedish one, but would now only use locally produced meatballs, she said.
"This is an extraordinary effort to ensure that no one is worried," Magnusson told The Associated Press.
She added that two weeks ago Ikea tested a range of frozen food products, including meatballs, and found no traces of horse meat. The company plans to conduct its own tests to "validate" the Czech results, she said.
Ikea's North America branch said the U.S. stores get their meatballs from a U.S. supplier.
"Based on the results of our mapping, we can confirm that the contents of the meatballs follow the Ikea recipe and contain only beef and pork from animals raised in the U.S. and Canada," Ikea North America spokeswoman Mona Astra Liss said in a statement.
Ikea is known for its assemble-it-yourself furniture but its trademark blue-and-yellow megastores also have cafeteria-style restaurants offering Swedish dishes such as meatballs served with boiled or mashed potatoes, gravy and lingonberry jam.
European Union officials met Monday to discuss tougher food labeling rules after the discovery of horse meat in a wide range of frozen supermarket meals that were supposed to contain beef or pork. So far those foods include meatballs, burgers, kebabs, lasagna, pizza, tortelloni, ravioli, empanadas and meat pies, among other items.
Authorities say the scandal is a case of fraudulent labeling but does not pose a health risk.
Gunnar Dafgard AB, a family-owned frozen foods company in southwestern Sweden that supplies Ikea's meatballs in Europe, posted a brief statement on its website saying "the batch in question has been blocked and we are investigating the situation."
Spokesman Ola Larsson said the company was conducting its own DNA tests and wouldn't comment further until it has those results.
Sweden's food safety authority said it wasn't taking any action but was waiting for Czech authorities to specify the quantity of horsemeat detected.
"If it's less than 1 percent it could mean that they handled horsemeat at the same facility. If it's more, we assess that it's been mixed into the product," said Karin Cerenius of Sweden's National Food Agency.
The Czech authority said a total of 760 kilograms (1,675 pounds) of the meatballs were stopped from reaching the shelves. It also said it found horse meat in beef burgers imported from Poland during random tests of food products.
"Unfortunately, the testing method we use detects just the quality ... the presence or non-presence of horse DNA," said Jan Vana, a senior official at the State Veterinary Administration. "At the moment, we can't say the quantity of it."
Spanish authorities, meanwhile, announced that traces of horse meat were found in a beef cannelloni product by one of the brands of Nestle, a Switzerland-based food giant.
In a statement on its website, Nestle Spain said it was withdrawing six "La Cocinera" products and one "Buitoni" product from store shelves. It said it was taking the action after traces of horse meat were found in beef bought from a supplier in Spain and that it was taking legal action against the company.
Processed food products ? a business segment with traditionally low margins that often leads producers to hunt for the cheapest suppliers ? often contain ingredients from multiple suppliers in different countries, who themselves at times subcontract production to others, making it hard to monitor every link in the production chain.
Standardized DNA checks with meat suppliers or more stringent labeling rules on disclosing the origin of processed food's ingredients will add costs that producers will most likely hand over to consumers, making food more expensive.
The scandal has created a split in the European Union between nations like Britain, which see further rules as a protectionist hindrance of free trade under the 27-nation bloc's single market, and those calling for tougher regulation, including Austria and Germany.
"Consumers have every right to the greatest-possible transparency," German Agriculture Minister Ilse Aigner said.
At the meeting in Brussels, several EU agriculture ministers called upon the Commission, the bloc's executive arm, to speed up presenting a proposal on tougher regulation by this summer.
The scandal began in Ireland in mid-January when the country announced the results of its first-ever DNA tests on beef products. It tested frozen beef burgers taken from store shelves and found that more than a third of brands at five supermarkets contained at least a trace of horse. The sample of one brand sold by the British supermarket kingpin Tesco had more than 25 percent horse meat.
___
Associated Press writers Juergen Baetz in Brussels, Karel Janicek in Prague and Ciaran Giles in Madrid contributed to this report.
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